Korean J Obstet Gynecol.  2006 Nov;49(11):2399-2403.

A Case of Essential Thrombocythemia Diagnosed During Pregnancy

Affiliations
  • 1Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Korea. sohnis@kuh.ac.kr
  • 2Department of Anesthesiology, Konkuk University School of Medicine, Seoul, Korea.
  • 3Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
  • 4Department of Internal Medicine, Division of Hematology-Oncology, Konkuk University School of Medicine, Seoul, Korea.

Abstract

Essential thrombocythemia (ET) is a chronic myeloproliferative disease characterized by a markedly elevated platelet count in the peripheral blood due to excessive proliferation of bone marrow megakaryocytes. When the disease affects women during pregnancy, an adverse obstetric outcome is possible: miscarriages, intrauterine growth restriction, preterm delivery, intrauterine fetal death, preeclampsia. Maternal complications, both thrombotic and hemorrhagic, were reported relatively infrequently. Various treatments as acetylsalicylic acid, hydroxyurea, anagrelide, heparin, interferon-alpha and plateletpheresis have been proposed to improve the pregnancy. Our case was a 38 years old multiparous women at 37 weeks of gestation with preeclampsia, intrauterine growth restriction. Under the impression of oligohydramnios and fetal distress, an emergency cesarean section was performed under epidural anesthesia. During cesarean section, sudden cardiac arrest with unknown cause was developed, and successful resuscitation was done. After cesarean section, patient continued to elevate platelet count. So bone marrow aspiration and biopsy were performed and showed essential thrombocythemia. We report a case of essential thrombocythemia diagnosed during pregnancy with brief review of the literature.

Keyword

Pregnancy; Essential thrombocythemia; Preeclampsia; IUGR

MeSH Terms

Abortion, Spontaneous
Adult
Anesthesia, Epidural
Aspirin
Biopsy
Bone Marrow
Cesarean Section
Death, Sudden, Cardiac
Emergencies
Female
Fetal Death
Fetal Distress
Fetal Growth Retardation
Heparin
Humans
Hydroxyurea
Interferon-alpha
Megakaryocytes
Oligohydramnios
Platelet Count
Plateletpheresis
Pre-Eclampsia
Pregnancy*
Resuscitation
Thrombocythemia, Essential*
Aspirin
Heparin
Hydroxyurea
Interferon-alpha
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