Korean J Obstet Gynecol.  2006 Aug;49(8):1697-1705.

The usefulness of vascular endothelial growth factor as a prognostic factor in uterine cervix cancer

• Seo KY
• Myong NH
• Park JW

Abstract

OBJECTIVE
This study was designed to determine the relationship between the VEGF (Vascular Endothelial Growth Factor) expression and histopathologic prognostic factors and 5-year survival rate.
METHODS
We examined the expression of the VEGF by immunohistochemical staining in 40 specimens collected from invasive uterine cervix cancer patients. We compared the results of relationship between the VEGF expression and several histopathologic prognostic factors by using Fisher exact test for statistical analysis.
RESULTS
All specimens showed low or high immunoreactivity. There was no significant correlation between the expression of the VEGF and histopathologic prognostic factors (p>0.05) except for pathological cell types (p<0.05). Parametrial invasion, the stage and age showed statistically significant correlation with 5 year survival rate (p<0.05). There was no statistically significant correlation between the VEGF expression and 5 year survival rate.
CONCLUSION
VEGF expression had no relation with prognostic factors except for histopathologic cell types. Its expression may not play an important role in the prognosis of the uterine cervix cancer patients.

Keyword

Uterine cervix cancer; Vascular endothelial growth factor; Survival prognosis; Immunohistochemistry

MeSH Terms

Cervix Uteri*
Female
Humans
Immunohistochemistry
Prognosis
Survival Rate
Vascular Endothelial Growth Factor A*
Vascular Endothelial Growth Factor A