Korean J Obstet Gynecol.
2005 Jul;48(7):1654-1662.
Chorionic Villus Sampling: Clinical and Cytogenetic Study of the First 1,058 Cases in YUMC from 1984 to 2004 years
- Affiliations
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- 1Department of Obstetrics and Gynecology, College of Medicine, Yonsei University, Seoul, Korea. ob@yumc.yonsei.ac.kr
- 2Divison of Prenatal Genetic Clinic, College of Medicine, Yonsei University, Seoul, Korea.
- 3Department of Genetic Laboratory, College of Medicine, Yonsei University, Seoul, Korea.
Abstract
OBJECTIVE
This study was performed to evaluate the feasibility, accuracy and safety of Chorionic Villus Sampling (CVS).
METHODS
We analyzed the outcome of 1,058 cases of CVS performed for prenatal genetic diagnosis between 7 and 12 weeks of gestation in the outpatient prenatal genetic clinic in Yonsei University Medical Center (1,030 cases by trans-cervical method and 28 cases by trans-abdominal). Fetal Karyotyping was obtained by direct or indirect culture methods using Gimsa and Gimsa-Banding.
RESULTS
Advanced maternal age was the most common indication for CVS (34.7%). The overall sampling success rate was 98% (1040/ 1,058), representing 92.5% in 7 to 8 weeks, 98.0% in 9 to 10 weeks, and 98.9% in 11 to 12weeks of gestation. The majority of cases (94.6%) required one or two aspirations. Cytogenetic analysis routinely included direct overnight and long-term culture methods, which revealed 27 chromosomal abnormalities (2.6%). Of 1,040 cases in which CVS were successful, 989 delivered normal baby, 23 resulted in fetal loss, 25 had therapeutic termination (24 with chromosome abnormalities and 1 with normal chromosome with huge myoma), and 3 with chromosome abnormalities were loss to follow up. The overall fetal loss rate was 2.2% (23/1,058). No congenital anomalies were found to be related to CVS in these series.
CONCLUSION
When performed by experienced operators and cytogeneticists beyond 9 weeks of gestation, CVS is a feasible, accurate and safe method for prenatal genetic diagnosis capable of replacing genetic amniocentesis.
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