Korean J Obstet Gynecol.  2003 Nov;46(11):2113-2117.

N-acetyl Transferase 2 Gene Polymorphisms in Patients with Endometriosis

Affiliations
  • 1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea.
  • 2Institute of Reproductive Medicine and Population, Seoul National University College of Medicine, Korea.
  • 3Medical Research Center, Seoul National University College of Medicine, Korea.
  • 4Department of Pathology, Seoul National University College of Medicine, Korea.
  • 5Department of Obstetrics and Gynecology, Busan University College of Medicine, Korea.

Abstract


OBJECTIVE
To explore the association of the N-acetyl transferase 2 (NAT 2) gene polymorphisms with endometriosis.
METHODS
One hundred seventy-two women with surgically or histologically diagnosed endometriosis of stages I-IV, and 205 patients with no evidence of endometriosis by laparoscopy or laparotomy served as control. Genotype distribution of NAT 2 polymorphisms and frequencies of slow and fast acetylators in affected women and controls were evaluated.
RESULTS
There was no statistically significant difference in the genotype distribution of NAT 2 polymorphisms and frequencies of slow and fast acetylators between the patients with endometriosis and the controls.
CONCLUSION
These results suggest that N-acetyl transferase 2 gene polymorphisms is not associated with the risk for endometriosis in the Korean population.

Keyword

Endometriosis; N-acetyl transferase 2; NAT 2 gene; Polymorphism

MeSH Terms

Endometriosis*
Female
Genotype
Humans
Laparoscopy
Laparotomy
Transferases*
Transferases
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