Korean J Obstet Gynecol.
2003 Nov;46(11):2113-2117.
N-acetyl Transferase 2 Gene Polymorphisms in Patients with Endometriosis
- Affiliations
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- 1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea.
- 2Institute of Reproductive Medicine and Population, Seoul National University College of Medicine, Korea.
- 3Medical Research Center, Seoul National University College of Medicine, Korea.
- 4Department of Pathology, Seoul National University College of Medicine, Korea.
- 5Department of Obstetrics and Gynecology, Busan University College of Medicine, Korea.
Abstract
OBJECTIVE
To explore the association of the N-acetyl transferase 2 (NAT 2) gene polymorphisms with endometriosis.
METHODS
One hundred seventy-two women with surgically or histologically diagnosed endometriosis of stages I-IV, and 205 patients with no evidence of endometriosis by laparoscopy or laparotomy served as control. Genotype distribution of NAT 2 polymorphisms and frequencies of slow and fast acetylators in affected women and controls were evaluated.
RESULTS
There was no statistically significant difference in the genotype distribution of NAT 2 polymorphisms and frequencies of slow and fast acetylators between the patients with endometriosis and the controls.
CONCLUSION
These results suggest that N-acetyl transferase 2 gene polymorphisms is not associated with the risk for endometriosis in the Korean population.
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