Korean J Obstet Gynecol.  2003 Jun;46(6):1151-1158.

Influence of Antiphospholipid Antibodies on IVF-ET Outcome in Women Referred for IVF-ET

• Park EJ
• Kang CS
• Kim SH
• Chae HD
• Kim CH
• Kang BM

Abstract

OBJECTIVE
The present study was designed to investigate if antiphospholipid antibodies (aPL) could affect the pregnancy outcome in women undergoing in vitro fertilization and embryo transfer (IVF-ET).
MATERIALS AND METHODS
From January 1997 to June 2001, 9 women with aPL who underwent IVF- ET were studied. Forty-five women without aPL who underwent IVF-ET served as control. Anticardiolipin antibody (aCL) IgG, IgM, lupus anticoagulant (LA) were assayed with use of standardized enzyme linked immunosorbent assays (ELISA) and dilute Russell's viper venom time (dRVVT) test. Long protocol of gonadotropin-releasing hormone agonist (GnRH-a) was used for controlled ovarian hyperstimulation (COH) in all patients. Statistical analysis was performed using Student's t-test, Fisher's exact test, and x2 test as appropriate. Statistical significance was defined as p<0.05.
RESULTS
There were no significant differences between the study and control groups in patient characteristics such as age, infertility duration, hormonal profile, cause of infertility and number of previous IVF attempts. There were also no significant differences between two groups with respect to clinical response to COH and IVF results such as number of retrieved oocytes, fertilization rate, number of embryos frozen and number of embryos transferred. The clinical pregnancy rate per cycle seemed to be higher in the study group than in the control group (25.0% vs 14.9%), however, the difference was not statistically significant. Miscarriage rate per clinical pregnancy was significantly higher in the study group at 67.0% (4/6) compared with 29.4% (5/17) in the control group. Delivery rate per clinical pregnancy was significantly lower in the study group at 16.7% (1/6) compared with 58.8% (5/17) in the control group.
CONCLUSION
Women with aPL undergoing IVF-ET may have similar IVF outcome compared with women without aPL, except miscarriage rate per clinical pregnancy.

Keyword

Antiphospholipid antibody (aPL); In vitro fertilization and embryo transfer (IVF-ET)

MeSH Terms

Abortion, Spontaneous
Antibodies, Anticardiolipin
Antibodies, Antiphospholipid*
Embryo Transfer
Embryonic Structures
Female
Fertilization
Fertilization in Vitro
Gonadotropin-Releasing Hormone
Humans
Immunoglobulin G
Immunoglobulin M
Infertility
Lupus Coagulation Inhibitor
Oocytes
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Prothrombin Time
Antibodies, Anticardiolipin
Antibodies, Antiphospholipid
Gonadotropin-Releasing Hormone
Immunoglobulin G
Immunoglobulin M
Lupus Coagulation Inhibitor