Blood Res.  2013 Mar;48(1):51-54. 10.5045/br.2013.48.1.51.

Blood group phenotype frequencies in blood donors from a tertiary care hospital in north India

Affiliations
  • 1Department of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi, India. nuts_medico@rediffmail.com

Abstract

BACKGROUND
Knowledge about the frequency of red blood cell-antigen phenotypes in a population can be helpful in the creation of a donor data bank for the preparation of indigenous cell panels and for providing antigen-negative compatible blood to patients with multiple alloantibodies.
METHODS
ABO and RhD blood grouping was performed on 9,280 continuous voluntary and replacement donors. For other rare blood groups, 508 ACD blood samples were obtained from the donors at the Blood Bank of the Department of Transfusion Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India. Blood group antigens were determined by tube method using anti-sera (Bio-Rad, USA), and the phenotype frequencies were expressed as percentages.
RESULTS
Group B (37.39%) was the most common, followed by group O (31.85%). R1R1 and rr were the most common phenotypes amongst Rh positive and Rh negative groups, respectively. A rare phenotype R2Rz was found in one donor. For Kidd and Duffy blood group systems, Jk (a+b+) and Fy (a+b+) were the most common phenotypes (46.06% and 48.03%, respectively). The most common phenotypes for MNSs, Lu, and Kell blood groups were M+N+, S-s+, Lu (a-b+), and K-k+, respectively. A very rare case of Fy (a-b-) and Jk (a-b-) was found in a single donor.
CONCLUSION
This study is the first small step to create a rare donor data bank and to prepare indigenous cell panels to provide compatible blood to all multi-transfused alloimmunized patients.

Keyword

Blood group; MNS; ABO; Rh; Kell; Kidd; Duffy

MeSH Terms

Blood Banks
Blood Donors
Blood Group Antigens
Blood Grouping and Crossmatching
Duffy Blood-Group System
Humans
India
Phenotype
Tertiary Healthcare
Tissue Donors
Blood Group Antigens
Duffy Blood-Group System

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