Korean J Ophthalmol.  1992 Dec;6(2):100-104. 10.3341/kjo.1992.6.2.100.

Positive family history of glaucoma is a risk factor for increased IOP rather than glaucomatous optic nerve damage (POAG vs OH vs normal control)

• Uhm KB
• Shin DH

• KMID: 2270697
• DOI: http://doi.org/10.3341/kjo.1992.6.2.100

Abstract

To elucidate the family history of glaucoma (FHG) as a risk factor for ocular hypertension(OH) vs glaucomatous optic nerve damage, we reviewed the clinical records of 361 primary open-angle glaucoma(POAG) patients, 178 OH subjects, and 927 normal controls randomly selected from an urban medical center eye clinic. The prevalence of a positive FHG was 27% in the POAG patients, 47% in the OH subjects, and 11% in the normal controls. Whereas a positive FHG was a significant risk factor for both OH and glaucoma compared to normal control subjects (OR = 7.56, 95% CI: 5.27-10.85, P < .0001 for OH; OR = 3.15, 95% CI: 2.31-4.31, P < .0001), it was a risk factor more significantly for OH than for glaucoma being significantly more prevalent in OH than in POAG (OR = 2.40, 95% CI: 1.65-3.49, P < .0001). These results suggest the importance of additional risk factors other than IOP for glaucomatous optic nerve damage.

Keyword

family history of glaucoma; risk factors; primary open-angle glaucoma; ocular hypertension

MeSH Terms

Aged
Family Health
Female
Glaucoma, Open-Angle/epidemiology/*genetics
Humans
*Intraocular Pressure
Male
Ocular Hypertension/epidemiology/*genetics
Optic Nerve Diseases/epidemiology/*genetics
Prevalence
Questionnaires
Random Allocation
Risk Factors