Three Cases of Squamous Cell Carcinoma of the Ovary Arising in Mature Cystic Teratoma

Kim, E K; Ryu, S Y; Kim, S Y; Kim, J W; Park, N H; Park, I A; Song, Y S; Kang, S B; Lee, H P

Abstract

Squamous cell carcinoma of the ovary is very rare malignant tumor usually originating from the malignant transformation of mature cystic teratoma. Because of its rarity, the clinico-pathologic characteristics are not well established. We have experienced three cases of squamous cell carcinoma of the ovary arising in mature cystic teratoma. We investigated the clinical profiles and histopathologic features of these patients, and examined the presence of p53 mutations with immunohistochemical method. First, a 54-year-old woman with FIGO stage Ia survived for 124 months without adjunctive chemotherapy after total hysterectomy and bilateral salpingo-oophorectomy. Second, a 75-year-old woman with FIGO stage IIIc who had rejected adjunctive chemotherapy after total hysterectomy and bilateral salpingo-oophorectomy expired 3 months later. Third, a 39-year-old premenopausal woman with FIGO stage IIIb recurred after 7 months in spite of surgery and adjunctive chemotherapy. We report these three cases of squamous cell carcinoma arising in mature cystic teratoma of the ovary with brief review of literature.