Asian Oncol Nurs.  2012 Feb;12(1):84-91. 10.5388/aon.2012.12.1.84.

Related Factors to Quality of Life among Hospitalized Cancer Patients Undergoing Chemotherapy

  • 1Chonnam National University, Gwangju, Korea.
  • 2College of Nursing, Chonnam National University, Chonnam Research Institute of Nursing Science, Gwangju, Korea.
  • 3Christian Nursing College, Gwangju, Korea.
  • 4Chonnam Research Institute of Nursing Science, Gwangju, Korea.


The purpose of this study was to identify relationships between quality of sleep, symptom cluster, depression, environmental disorder, and quality of life among hospitalized cancer patients.
The subjects were 114 patients who underwent chemotherapy for colon cancer, gastric cancer, gynecologic cancer and breast cancer. They were recruited from the cancer center of a university hospital. Data were collected from August 4th to 30th, 2011. The questionnaires included the Korean sleep scale A (quality of sleep), MDASI-K (symptom cluster), the environmental sleep disturbing scale, Zung's depression scale, and the Korean version of EORTC QLQ-C30. The collected data was analyzed by t-test, ANOVA, multiple regression analysis using the SPSS 19.0 program.
Functional QOL was negatively associated with symptom QOL (r=-.798, p<.001). Symptom cluster, depression, & spouse (46.3%) were the most powerful predictors for functional QOL (46.3%) and symptom QOL (53.4%).
It is evident that oncology nurses need to evaluate two dimensions of quality of life for cancer patients, for example, functional and symptom QOL. We recommend nurses develop specific protocols for relieving physical symptoms and alleviating depression, and furthermore test the effectiveness of them.


Sleep Disorder; Depression; Cancer Patient; Quality of Life

MeSH Terms

Breast Neoplasms
Colonic Neoplasms
Quality of Life
Stomach Neoplasms
Surveys and Questionnaires

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1. Jensen DP, Herr KA. Sleeplessness. Nurs Clin North Am. 1993. 28:385–405.
2. Song MS, Kim SM, Oh JJ. Sleep pattern and related factors among community dwelling elderly. Seoul J Nurs. 1997. 11:24–38.
3. Vena C, Parker K, Cunningham M, Clark J, McMillan S. Sleep-wake disturbances in people with cancer part I: An overview of sleep, sleep regulation, and effects of disease and treatment. Oncol Nurs Forum. 2004. 31:735–746.
4. Davidson JR, MacLean AW, Brundage MD, Schulze K. Sleep disturbance in cancer patients. Soc Sci Med. 2002. 54:1309–1321.
5. Mystakidou K, Parpa E, Tsilika E, Pathiaki M, Patiraki E, Galanos A, et al. Sleep quality in advanced cancer patients. J Psychosom Res. 2007. 62:527–533.
6. Kim HS, Oh EG. An explanatory model for sleep disorders in people with cancer. J Korean Acad Nurs. 2011. 41:460–470.
7. Seo WS. Cancer-related sleep disorders. Sleep Med Psychophysiol. 2009. 16:10–15.
8. Park JH, Lee SJ, Gwak JI, Shim JY, Lee JK. Sleep quality of breast cancer patients receiving chemotherapy in the outpatients setting. Korean J Fam Med. 2010. 31:778–785.
9. Byar KL, Ann MB, Suzanne LB, Melissa AC. Impact of adjuvant breast cancer chemotherapy on fatigue, other symptoms, and quality of life. Oncol Nurs Forum. 2006. 33:E18–E26.
10. Vena C, Kathy PP, Rebecca A, Donald LB, Sanjay J, Laura K. Sleep-wake disturbances and quality of life in patients with advanced lung cancer. Oncol Nurs Forum. 2006. 33:761–769.
11. Bardwell WA, Jacqueline MM, Cheryl LR, Vicky AN, Cynthia AT, Janice AC, et al. Health-related quality of life in women previously treated for early-stage breast cancer. Psychooncology. 2004. 13:595–604.
12. Redeker NS. Insomnia, fatigue, anxiety, depression, and quality of life of cancer patients undergoing chemotherapy. Sch Inq Nurs Pract. 2000. 14:275–290.
13. Smith EM, Gomm SA, Dickens CM. Assessing the independent contribution to quality of life from anxiety and depression in patients with advanced cancer. Palliat Med. 2003. 17:509–513.
14. Johnson JR, Temple R. Food and drug administration requirements for approval of new anticancer drugs. Cancer Treat Rep. 1985. 69:1155–1157.
15. Gotay CC, Kawamoto CT, Bottomley A, Efficace F. The prognostic significance of patient-reported outcomes in cancer clinical trials. J Clin Oncol. 2008. 26:1355–1363.
16. Liu L, Fiorentino L, Natarajan L, Parker BA, Mills PJ, Sadler GR, et al. Pre-treatment symptom cluster in breast cancer patients is associated with worse sleep, fatigue and depression during chemotherapy. Psychooncology. 2009. 18:187–194.
17. Kim GD, Kim KH. Symtom cluster and quality of life in patients with breast cancer undergoing chemotherapy. Korean J Adult Nurs. 2011. 23:434–445.
18. Cohen J. Statistical power analysis for behavioral science. 1988. New York: Academic Publishers.
19. Paik YN. Sleep disturbing factors and the relative significance in sleep of hospitalized elderly patients [dissertation]. 2000. Seoul: Seoul National Univ..
20. Oh JJ, Song MS, Kim SM. Development and validation of Korean sleep scale A. J Korean Acad Nurs. 1998. 28:563–572.
21. Yun YH, Mendoza TR, Kang IO, You CH, Roh JW, Lee CG, et al. Validation study of the Korean version of the M. D. Anderson Symptom Inventory. J Pain Symptom Manage. 2006. 31:345–351.
22. Zung WW. A Self-rating depression scale. Arch Gen Psychiatry. 1965. 12:63–70.
23. Yun YH, Park YS, Lee ES, Bang SM, Heo DS, Park SY, et al. Validation of the Korean version of the EORTC QLQ-C30. Qual Life Res. 2004. 13:863–868.
24. Ko MS. A study of sleep pattern, factors of sleep disturbance and sleep enhancement behaviors in hospitalized elderly patients [dissertation]. 2002. Seoul: Chung-Ang Univ..
25. Cheng KK, Lee DT. Effects of pain, fatigue, insomnia, and mood disturbance on functional status and quality of life of elderly patients with cancer. Critical Reviews in Oncology/Hematology. 2011. 78:127–137.
26. Paltiel O, Marzec-Boguslawska A, Soskolne V, Massalha S, Avitzour M, Pfeffer R, et al. Use of tranquilizers and sleeping pills among cancer patients is associated with a poorer quality of life. Qual Life Res. 2004. 13:1699–1706.
27. Theobald DE. Cancer pain, fatigue, distress, and insomnia in cancer patients. Clin Cornerstone. 2004. 6:Suppl 1D. S15–S21.
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