Korean J Med.  2014 May;86(5):603-607.

A Gangliocytic Paraganglioma Presenting as a Submucosal Tumor in the Ampulla

  • 1Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea. 20110235@kuh.ac.kr
  • 2Department of Pathology, Konkuk University School of Medicine, Seoul, Korea.


A gangliocytic paraganglioma (GP) is a rare benign neuroendocrine tumor. However, its origin remains unclear. It is seen most frequently in the second portion of the duodenum. At endoscopy, a GP characteristically appears as a pedunculated nodular submucosal tumor with erosions and surface ulcers. The histological diagnosis is usually made from endoscopic biopsies showing the presence of epithelioid, spindle, and ganglion cells. We experienced a case of GP in a 38-year-old female who was referred because of a possible ampullary tumor. The endoscopic images showed a 1.5-cm, oval ampullary tumor covered with normal mucosa. An endoscopic biopsy showed chronic duodenitis. The tumor was removed by an endoscopic papillectomy. We report a case of duodenal GP that presented as a submucosal tumor that was treated with a papillectomy and review the literature.


Paraganglioma; Gangliocytic; Endoscopic mucosal resection
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