Korean J Med.  2015 Feb;88(2):224-230. 10.3904/kjm.2015.88.2.224.

Two Cases of Primary Esophageal Diffuse Large B Cell Lymphoma: Therapeutic Considerations and a Literature Review

• Kim JH
• Jung YH
• Woo IS
• Han CW
• Seo MW
• Yoo SH
• Ha SY

• KMID: 2269157
• DOI: http://doi.org/10.3904/kjm.2015.88.2.224

Abstract

Primary esophageal lymphoma is very rare, and most reported cases are histologically mucosa-associated lymphoid tissue lymphoma. Therefore, the principle treatment strategy for primary esophageal lymphoma focuses on local treatments, such as endoscopic mucosal resection or radiation therapy, but systemic chemotherapy plays the central role in the treatment of diffuse large B cell lymphoma (DLBCL). Generally, standard treatment for DLBCL is six or three cycles of R-CHOP chemotherapy followed by involved field radiation therapy according to stage. However, the optimal treatment strategy for primary esophageal DLBCL, and the role of additional radiation is not settled, due to a paucity of cases. Moreover, the clinical characteristics related to the etiology and natural course are also unknown. Here, we present two cases of primary esophageal DLBCL with a literature review.

Keyword

Esophagus; Diffuse large-cell lymphoma

MeSH Terms

Drug Therapy
Esophagus
Lymphoma
Lymphoma, B-Cell*
Lymphoma, B-Cell, Marginal Zone
Lymphoma, Large B-Cell, Diffuse