Korean J Med.  2015 Feb;88(2):127-134. 10.3904/kjm.2015.88.2.127.

Treatment of Heart Failure with Reduced Ejection Fraction: Current Update

• Park JJ
• Choi DJ

• KMID: 2269141
• DOI: http://doi.org/10.3904/kjm.2015.88.2.127

Abstract

The prevalence of heart failure (HF) has been steadily increasing and it now creates an enormous social and economic burden. HF is a syndrome characterized by a high mortality rate, frequent hospitalization, a reduced quality of life, and a complex therapeutic regimen. In the last three decades, major progress in both the diagnosis and management of HF has taken place, and the pharmacologic and non-pharmacologic advances have led to a significant improvement in survival and symptoms in HF patients. After an accurate diagnosis, a proper HF management plan requires a multi-level team approach comprised of the correct combination of drug therapy, device therapy, and surgery, including heart transplantation. In this review, we focused on the pharmacologic and non-pharmacologic treatment strategies for HF with reduced ejection fraction. The goal was to develop treatment guidelines based on significant evidence derived from large clinical trials.

Keyword

Systolic heart failure; Practice guideline

MeSH Terms

Diagnosis
Drug Therapy
Heart Failure*
Heart Failure, Systolic
Heart Transplantation
Hospitalization
Humans
Mortality
Prevalence
Quality of Life