Korean J Med.  2015 Jul;89(1):113-116. 10.3904/kjm.2015.89.1.113.

Treatment of a Patient with Kaposi's Sarcoma Arising during Hemodialysis with the Multikinase Inhibitor Pazopanib

• Chun YJ
• Choi AR
• Yang SY
• Kim HE
• Cho JH
• Lim JY
• Cho JY

• KMID: 2269060
• DOI: http://doi.org/10.3904/kjm.2015.89.1.113

Abstract

Kaposi's sarcoma (KS) is an unusual multifocal neoplastic angioproliferative disorder. We herein report a case of classic KS that occurred in a patient receiving hemodialysis for 7 years. The patient had a history of chronic renal failure due to glomerulonephritis for 20 years. Multiple reddened violaceous patches, plaques, and nodules were found on the right knee. Biopsy revealed positivity for human herpesvirus 8 (KS-associated herpesvirus) consistent with KS. Pazopanib, a multitarget tyrosine kinase inhibitor, is an effective agent for treatment of advanced soft tissue sarcoma. The patient received pazopanib for 6 months investigate its effects on KS. The skin lesions and painful symptoms showed improvement. Further studies are required to determine the mechanism underlying the anticancer action of pazopanib and the pathogenesis of KS.

Keyword

Pazopanib; Sarcoma, Kaposi; Renal dialysis

MeSH Terms

Biopsy
Glomerulonephritis
Herpesvirus 8, Human
Humans
Kidney Failure, Chronic
Knee
Protein-Tyrosine Kinases
Renal Dialysis*
Sarcoma
Sarcoma, Kaposi*
Skin
Protein-Tyrosine Kinases