Korean J Med.
2013 Feb;84(2):295-298.
A Case of Systemic Lupus Erythematosus Occurring after H1N1 Influenza Vaccination
- Affiliations
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- 1Department of Internal Medicine, Eulji University Hospital, Eulji University College of Medicine, Daejeon, Korea. redsea98@eulji.ac.kr
- 2Department of Pathology, Eulji University Hospital, Eulji University College of Medicine, Daejeon, Korea.
Abstract
- The recent worldwide outbreak of H1N1 has led to the universal administration of H1N1 influenza vaccination, including in South Korea. Several complications have been reported with use of H1N1 influenza vaccine, but systemic lupus erythematosus (SLE) has not been reported as a complication until now. Here, we report a case of SLE occurrence after H1N1 influenza vaccination. A 17-year-old girl who had not been diagnosed with SLE was hospitalized with fever, myalgia, and arthralgia after H1N1 influenza vaccination. Laboratory tests revealed increased levels of antinuclear antibody and anti-ds-DNA antibody, and decreased levels of C3 and C4 as well as proteinuria. The pathological findings confirmed a diagnosis of lupus nephritis. The patient was treated with high-dose corticosteroid and hydroxychloroquine. This is the first report of SLE following H1N1 influenza vaccination in South Korea.
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