Ann Dermatol.  2010 Aug;22(3):333-336. 10.5021/ad.2010.22.3.333.

A Case of Dermatofibroma of the Upper Lip

Affiliations
  • 1Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea. drseo@hanafos.com
  • 2Department of Pathology, College of Medicine, Chung-Ang University, Seoul, Korea.

Abstract

Dermatofibroma (DF) is a common benign mesenchymal tumor composed of fibroblastic and histiocytic cells. It occurs anywhere on the body surface but has a propensity for the extremities. To our knowledge, DF arising in the oral cavity, especially on the lip, is quite rare. DFs of the head and neck region have been known to be most often of the cellular type and frequently recur, so a wider initial excision is recommended. Herein we report a case of DF in a 41-year-old female who presented with a deep-seated nodule on her upper lip.

Keyword

Dermatofibroma; Lip

MeSH Terms

Adult
Extremities
Female
Fibroblasts
Head
Histiocytoma, Benign Fibrous
Humans
Lip
Mouth
Neck

Figure

  • Fig. 1 Rubbery, firm, non-mobile nodule, 1.0×1.0 cm in diameter, on the upper lip with normal overlying labial mucosa and skin.

  • Fig. 2 (A) Histological findings show acanthosis of the epidermis and a poorly defined non-encapsulated deep dermal tumor (H&E, ×20). (B, C) The tumor was found to be composed of fibroblastic spindle cells in a storiform pattern, separating dermal collagen with a few histiocytes both in the superficial (B) and deep portions of the tumor (C) (H&E, ×200).

  • Fig. 3 (A) CD34 was negative in fibroblastic spindle cells and positive in vessels (×200). (B) Factor XIIIa was positive in only a few dendritic cells and negative in fibroblastic cells (×200). (C) CD68 was weak in spindle cells and strong in histiocytes (×200). (D) Smooth muscle actin (SMA) was strong in fibroblastic spindle cells (×200).


Reference

1. Calonje E, Mentzel T, Fletcher CD. Cellular benign fibrous histiocytoma. Clinicopathologic analysis of 74 cases of a distinctive variant of cutaneous fibrous histiocytoma with frequent recurrence. Am J Surg Pathol. 1994. 18:668–676.
2. Calonje E. Is cutaneous benign fibrous histiocytoma (dermatofibroma) a reactive inflammatory process or a neoplasm? Histopathology. 2000. 37:278–280.
Article
3. Hillis RE, Beasley JD 3rd. Fibrous histiocytoma of the lip: report of a case. J Oral Med. 1975. 30:81–83.
4. Hoffman S, Martinez MG Jr. Fibrous histiocytomas of the oral mucosa. Oral Surg Oral Med Oral Pathol. 1981. 52:277–283.
Article
5. MacLeod SP, Jones JL. Fibrous histiocytoma of the lip secondary to trauma: report of a case. J Oral Maxillofac Surg. 1992. 50:1091–1093.
Article
6. Gray PB, Miller AS, Loftus MJ. Benign fibrous histiocytoma of the oral/perioral regions: report of a case and review of 17 additional cases. J Oral Maxillofac Surg. 1992. 50:1239–1242.
Article
7. Yamada H, Ishii H, Kondoh T, Seto K. A case of benign fibrous histiocytoma of the upper lip in a 6-month-old infant. J Oral Maxillofac Surg. 2002. 60:451–454.
Article
8. Senear FE, Caro MR. Histiocytoma cutis. Arch Derm Syphilol. 1936. 33:209–226.
Article
9. Nestle FO, Nickoloff BJ, Burg G. Dermatofibroma: an abortive immunoreactive process mediated by dermal dendritic cells? Dermatology. 1995. 190:265–268.
Article
10. Zelger BW, Zelger BG, Rappersberger K. Prominent myofibroblastic differentiation. A pitfall in the diagnosis of dermatofibroma. Am J Dermatopathol. 1997. 19:138–146.
11. Zelger B. It's a dermatofibroma, CD34 is irrelevant! Am J Dermatopathol. 2002. 24:453–454.
Article
12. Mentzel T, Kutzner H, Rütten A, Hügel H. Benign fibrous histiocytoma (dermatofibroma) of the face: clinicopathologic and immunohistochemical study of 34 cases associated with an aggressive clinical course. Am J Dermatopathol. 2001. 23:419–426.
Article
13. Shlomi B, Mintz S, Jossiphov J, Horovitz I. Immunohistochemical analysis of a case of intraoral nodular fasciitis. J Oral Maxillofac Surg. 1994. 52:323–326.
Article
14. Beer M, Eckert F, Schmöckel C. The atrophic dermatofibroma. J Am Acad Dermatol. 1991. 25:1081–1082.
Article
15. Regezi JA, Zarbo RJ, Tomich CE, Lloyd RV, Courtney RM, Crissman JD. Immunoprofile of benign and malignant fibrohistiocytic tumors. J Oral Pathol. 1987. 16:260–265.
Article
16. Goldblum JR, Tuthill RJ. CD34 and factor-XIIIa immunoreactivity in dermatofibrosarcoma protuberans and dermatofibroma. Am J Dermatopathol. 1997. 19:147–153.
Article
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