Ann Dermatol.  2015 Feb;27(1):104-107. 10.5021/ad.2015.27.1.104.

Triple Combination of Systemic Corticosteroids, Excimer Laser, and Topical Tacrolimus in the Treatment of Recently Developed Localized Vitiligo

• Jang YH
• Jung SE
• Shin J
• Kang HY

• KMID: 2264852
• DOI: http://doi.org/10.5021/ad.2015.27.1.104

Abstract

No abstract available.

MeSH Terms

Adrenal Cortex Hormones*
Lasers, Excimer*
Tacrolimus*
Vitiligo*
Adrenal Cortex Hormones
Tacrolimus

Figure

• 

  Fig. 1 Complete repigmentation. (A) Before treatment and (B) after 3 months of triple combination treatmentin patients 1, 8, 10, and 11. (C) At the end of the 7-week follow up, patient 6 with Hashimoto's thyroiditis had developed some areas of depigmentation over the repigmented sites. (D) However, this lesion was also completely repigmented after 1 month of combination treatment with excimer laser and topical tacrolimus. The black arrows indicate depigmented lesions.

Reference

1. Taieb A, Alomar A, Böhm M, Dell'anna ML, De Pase A, Eleftheriadou V, et al. Vitiligo European Task Force (VETF). European Academy of Dermatology and Venereology (EADV). Union Européenne des Médecins Spécialistes (UEMS). Guidelines for the management of vitiligo: the European Dermatology Forum consensus. Br J Dermatol. 2013; 168:5–19.

2. Brazzelli V, Antoninetti M, Palazzini S, Barbagallo T, De Silvestri A, Borroni G. Critical evaluation of the variants influencing the clinical response of vitiligo: study of 60 cases treated with ultraviolet B narrow-band phototherapy. J Eur Acad Dermatol Venereol. 2007; 21:1369–1374.

3. Lee KJ, Choi YL, Kim JA, Kim MG, Lee JH, Yang JM, et al. Combination therapy of epidermal graft and systemic corticosteroid for vitiligo. Dermatol Surg. 2007; 33:1002–1003.

4. Parsad D, Pandhi R, Dogra S, Kumar B. Clinical study of repigmentation patterns with different treatment modalities and their correlation with speed and stability of repigmentation in 352 vitiliginous patches. J Am Acad Dermatol. 2004; 50:63–67.

5. Passeron T, Ostovari N, Zakaria W, Fontas E, Larrouy JC, Lacour JP, et al. Topical tacrolimus and the 308-nm excimer laser: a synergistic combination for the treatment of vitiligo. Arch Dermatol. 2004; 140:1065–1069.

6. Sassi F, Cazzaniga S, Tessari G, Chatenoud L, Reseghetti A, Marchesi L, et al. Randomized controlled trial comparing the effectiveness of 308-nm excimer laser alone or in combination with topical hydrocortisone 17-butyrate cream in the treatment of vitiligo of the face and neck. Br J Dermatol. 2008; 159:1186–1191.

7. Radakovic-Fijan S, Fürnsinn-Friedl AM, Hönigsmann H, Tanew A. Oral dexamethasone pulse treatment for vitiligo. J Am Acad Dermatol. 2001; 44:814–817.

8. Kim SM, Lee HS, Hann SK. The efficacy of low-dose oral corticosteroids in the treatment of vitiligo patients. Int J Dermatol. 1999; 38:546–550.

9. Taïeb A. Vitiligo as an inflammatory skin disorder: a therapeutic perspective. Pigment Cell Melanoma Res. 2012; 25:9–13.

10. Lee DY, Kim CR, Lee JH, Yang JM. Recent onset vitiligo treated with systemic corticosteroid and topical tacrolimus: Need for early treatment in vitiligo. J Dermatol. 2010; 37:1057–1059.