Korean J Obstet Gynecol.  2002 Apr;45(4):687-695.

Clinicopathologic Characteristics and Prognosis of Endometrial Cancer: A study of 56 Cases

Affiliations
  • 1Department of Obstetrics and Gynecology, College of Medicine, Kyung Hee University, Seoul Korea.

Abstract


OBJECTIVES
This study was performed to evaluate the clinicopathologic characteristics and prognosis of uterine endometrial cancer to identify risk factors of the therapeutic and prognostic values.
METHODS
This retrospective study was based on medical records including operation records and pathologic reports of 56 patients who underwent surgical treatment with histologically proven endometrial cancer at Kyung-Hee University Medical Center from Sep. 1979 to Aug. 2001. The survival of patients was determined by description of last follow up date in medical records. If more than 3 months passed from last follow up date, we used mail and phone call to identify the status of patients. Univariate analysis was carried out to compare the importance of prognostic variables.
RESULTS
The mean age of these patients was 52.4 years, the most common presenting symptom was abnormal vaginal bleeding (91.1%). All except 2 cases of papillary serous carcinoma (3.6%) and 1 case of clear cell carcinoma (1.8%) were endometrioid adenocarcinoma (94.6%). And there are 6 cases of endometrial carcinoma with squamous differentiation. The grades were classified into grade 1 (53.6%), grade 2 (26.8%), grade 3 (19.6%). The FIGO surgical stages were classified into stage\\'a5\\'b0 (55.4%), stage \\'a5\\'b1 (7.1%), stage \\'a5\\'b2 (30.4%), stage \\'a5\\'b3 (7.1%). Most of the patients (87.5%) were treated by surgery only or surgery followed by adjuvant radiotherapy. The overall 5 years survival rate (5YSR) was 65.6%: The FIGO surgical stage \\'a5\\'b0 83.3%; stage \\'a5\\'b1 66.7%; stage \\'a5\\'b2 37.5%; stage \\'a5\\'b3 33.3%. Recurrent case was only one case. The age, parity, and preoperative Pap test were not significant prognostic factors. The depth of myometrium invasion (p<0.05), FIGO surgical stage (p<0.05), peritoneal cytology (p<0.05) and lymph node metastasis (p<0.05) were significant prognostic factors by univariate analysis.
CONCLUSIONS
Although the number of patients was not enough, the depth of myometrial invasion, FIGO surgical stage and lymph node metastasis seemed to be significant prognostic factors of uterine endometrial cancer.

Keyword

Uterine endometrial cancer; Clinicopathologic characteristics; 5YSR; Prognostic factors

MeSH Terms

Academic Medical Centers
Animals
Carcinoma, Endometrioid
Endometrial Neoplasms*
Female
Follow-Up Studies
Humans
Lymph Nodes
Medical Records
Mice
Myometrium
Neoplasm Metastasis
Parity
Postal Service
Prognosis*
Radiotherapy, Adjuvant
Retrospective Studies
Risk Factors
Survival Rate
Uterine Hemorrhage
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