Obstetric outcome in women with a history of recurrent miscarriage

Hur, Kuol; Yang, Kwang Moon; Han, Jung Yeol; Han, Kuk Sun; Lee, Hong Bok; Kim, Jin Young; Song, In Ok; Song, Ji Hong; Yoo, Keun Jai; Jun, Jong Young; Kang, Inn Soo; Koong, Mi Kyoung

Abstract

OBJECTIVE
To obtain etiology and obstetric outcome of women who had a history of recurrent miscarriage.
METHODS
From 1 June 1998 to 30 June 2000, 82 patients who attended infertility & current miscarriage clinic at Samsungcheil hospital and progressed beyond 24 weeks gestation following pregnancy were included in this study. The control population was 154 pregnancies considering age and parity over the same period. Retrospectively, we analyse the etiology of recurrent miscarriage and compare obstetric outcomes of two groups.
RESULTS
The etiology of recurrent miscarriage was immunologic factor (36.6%), unexplained (30.4%), anatomic cause (13.4%), endocrinologic abnormality (13.4%) and chromosomal abnormality (5.6%). The rate of preterm delivery (11%) and incidence of pregnancy induced hypertention (8.5%) were significantly higher than those of control group (3.2% and 2.5% respectively). There was no significant difference in the rate of small for gestational age, oligohydroamnios, cesarean section, perinatal loss and the incidence of gestational diabetes mellitus.
CONCLUSION
The pregnancy with a history of recurrent miscarriage is associated with increased risk of pregnancy induced hypertension and preterm delivery and represent a population at high risk of obstetric problems. Therefore, close surveillance during antenatal period is required.