Korean J Obstet Gynecol.  2001 Jan;44(1):31-35.

Comparison of Misoprostol vaginal application and Sulprostone with cervical laminaria tent insertion in mid-trimester termination of pregnancy

• Kim HY
• Choi YR
• Yoo JG
• Lee JJ
• Song JH
• Hwang IS

Abstract

OBJECTIVE
To compare the abortion time, success rate and efficiency of application of intravaginal misoprostol versus intracervical laminaria insertion and intravenous sulprostone administration for mid-trimester pregnancy termination. MATERIAL: Patients requesting termination of second trimester pregnancy were randomized into two groups. In Group I, the women were given 200 microg tablet of misoprostol placed in the posterior vaginal fornix. In Group II, the women were given laminaria insertion in cervical canal with intravenous sulprostone administration. Altogether 50 subjects were recruited with 25 women in each group.
RESULTS
The mean interval from start of induction to vaginal delivery was 1480.84+/-37.73 minutes in Group I and 1236.16+/-77.59 minutes in Group II(p=0.232). The success rate of termination within 48 hours in Group I and Group II were 84%, 92%(p=0.384). There were no significant differences in the mean interval time and success rates. Measurement of blood loss(differs in hemoglobin between the admission and postabortive 24 hours) shows in Group I(1.0352+/-0.5774) and in Group II(1.5640+/-0.8976). Mean changes in hemoglobin level were significantly lesser in the misoprostol group(p=0.017). No serious complication occurred.
CONCLUSION
Intravaginal misoprostol appears to be acceptably safe and effective agents for second trimester pregnancy termination.

Keyword

pregnancy termination; misoprostol; laminaria; sulprostone(PGE2)

MeSH Terms

Female
Humans
Laminaria*
Misoprostol*
Pregnancy Trimester, Second
Pregnancy*
Misoprostol