A Cytogenetic Survey of the Mentally Retarded Children

Ju, Kap Soon; Lee, Hee Kyung

Abstract

OBJECTIVE
A cytogenetic survey of the mentally retarded children in Seoul City Welfare Center for the Mentally Retarded and St Peter school has been undertaken.
METHODS
The chromosome analysis was carried out in 92 males and in 66 females as a total of 158 cases.
RESULTS
Abnormal karyotypes were observed in 22.2% of the total cases (35/158). Autosome and sex chromosome anomaly were observed in 20.3%(32/158) and 1.9%(3/158) respectively. Of 35 cases of anomaly, 91.4%(32/35) was autosome anomaly and 8.6%(3/35), sex chromosome anomaly.
CONCLUSION
Down syndrome karyotype was the most frequent anomaly among autosome anomalies which was 62.5%(20/32) and other autosome anomalies were observed in 37.5%(12/32).