Korean J Obstet Gynecol.  1999 Jun;42(6):1297-1303.

The Effects of Myometritis on the Sensory Receptors in the Feline Uterus

Abstract


OBJECTIVE
To examine whether the inflammation can alter the sensitivity of primary afferents innervating uterus and its adjacent tissues, and to elucidate the role of substance P which are known to be released to the inflamed tissues.
METHODS
Total fourteen female cats were used, four cats were used for inflammation tests. Uterine inflammation was induced by 10% of mustard oil after papain [3mg/ml] treatment. These chemicals were injected into the uterine cavity. Other 10 cats were used for substance P [5 g] tests which was injected into the uterine circulation. The responses of hypogastric nerve to bradykinin injected into the uterine circulation were recorded before and after either treatments [inflammation or substance P] using electrophysiological method.
RESULTS
The neuronal responses to bradykinin were increased at 2 hours and 4 hours after uterine inflammation. As for substance P treatment, the responses of 8 of 11 thin myelinated [A ] nerve fibers were decreased after substance P treatment, those of all 10 of unmyelinated [C] nerve fibers were increased.
CONCLUSIONS
These results indicated that the afferents from the uterus responded to bradykinin more sensitively after inflammation and substance P which are released after inflammation may play a important role in uterine hyperalgesia.

Keyword

Myometritis; Bradykinin; Substance P; Neuronal response

MeSH Terms

Animals
Bradykinin
Cats
Female
Humans
Hyperalgesia
Inflammation
Mustard Plant
Myelin Sheath
Nerve Fibers
Neurons
Papain
Sensory Receptor Cells*
Substance P
Uterus*
Bradykinin
Papain
Substance P
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