Korean J Obstet Gynecol.  1998 Sep;41(9):2442-2446.

Effects of Continuously Added Oral Progestin ( Medroxyprogesterone Acetate ) on the Levels of Serum Lipid and Lipoprotein during Estrogen Replacement Therapy in Postmenopausal Women

• Kwon SC
• Ko YH
• Kim YT
• Kim YC
• Baik KD
• Kim C

Abstract

The purpose of this study is to evaluate the effects on serum lipid and lipoproteins of continuously added oral progestogen (Medroxyprogesterone Acetate) to conjugated equine estrogens in postmenopausal women. We studied on 158 menopausal women who had no hormonal therapy and no contraindication of hormonal replacement therapy. Group I patients (n: 88) after hysterectomy were given daily conjugated equine estrogen 0.625 mg for 12 months. Group II patients (n: 70) with uterus received dalily conjugated equine estrogen 0.625 mg and medroxypro gesterone acetate 2.5 mg for 12 months. Pre-and post-treatment evaluations of serum lipid profiles demonstrated significant decreases in total cholesterol (9.19% and 10.46%) and low-density lipoprotein cholesterol (10.20% and 14.98%) and significant increases in high-density lipoprotein cholesterol (17.42% and 15.92%) and triglyceride (22.47% and 26.22%) in group I and group II (p<0.05). Besides, there was no significant difference in the degree of changes of post-treatment serun levels in total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglycerides between the two groups. In conclusion, medroxyprogesterone acetate at low doses in continuously combined estrogen replacement therapy doses not oppose the beneficial estrogen induced lipoprotein changes.

Keyword

Menopause; Lipoprotein; Estrogen redplacement therapy; Progestogen

MeSH Terms

Cholesterol
Estrogen Replacement Therapy*
Estrogens*
Estrogens, Conjugated (USP)
Female
Humans
Hysterectomy
Lipoproteins*
Medroxyprogesterone Acetate*
Medroxyprogesterone*
Menopause
Triglycerides
Uterus
Cholesterol
Estrogens
Estrogens, Conjugated (USP)
Lipoproteins
Medroxyprogesterone
Medroxyprogesterone Acetate
Triglycerides