Korean J Nutr.
2005 May;38(4):307-312.
The Growth Inhibitory Effects of Atrina Pecitinata Fractions on Cancer Cell Lines
- Affiliations
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- 1Department of Food and Nutrition, Biotechnology, Korea.
- 2Marine Biotechnology Center for Biofunctional Material Industries, Korea.
- 3Silla University, Busan, Korea.
Abstract
- We investigated the growth inhibitory effects of Atrina pecitinata (AP) on the proliferation in human cancer cell lines in vitro. AP was extracted with methanol which was further fractionated into four diffferent types: methanol (APMM), haxane (APMH), butanol (APMB), and aquous layers (APMA). Among various partition layers, the APMM showed the strongest cytotoxic effects on all cancer cell lines which we used. In the MTT assay of AP fractions, the growth inhibitory effects was increased in proportion to its concentration. We observed quinone reductase (QR) induced effects in all fraction layers of AP on HepG2 cells. The QR induced effects of APMM on HepG2 cell at 80 microgram/mL concentration indicated 2.0 with a control value of 1.0.
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