Korean J Bone Metab.  2011 Nov;18(2):93-99.

Relationship between Bone Mineral Density, Erythropoiesis, and Calcium-Phosphorus-Parathyroid Hormone Status in End-stage Renal Disease Patients

• Oh YJ
• Hong S
• Min K
• Song JH
• Lee SY
• Kim SH
• Nam M
• Kim YS

Abstract

OBJECTIVES
Abnormal bone turnover and mineralization is the characteristic of the end-stage renal disease (ESRD) patients receiving dialysis treatment. Reduced bone mineral density (BMD) has been reported in ESRD patients in many recent studies. Recent study has demonstrated hypoxia increases the loss of bone mass whereas the use of erythropoietin (EPO) increases bone marrow mesenchymal stem cell in vitro, which is the commonly found in ESRD patients. The objective of the present study is to analyze the relationship between erythropoiesis and calcium, phosphorus, parathyroid hormone (PTH) status in ESRD patients.
METHODS
This study was a cross-sectional analysis of 183 ESRD patients (78 males, 105 females) on dialysis with mean age of 52 +/- 13 years and mean dialysis duration of 3.4 +/- 3.0 years. Duration and dose of EPO administration, hemoglobin, serum ferritin, and iron were checked in all subjects. BMD was evaluated by DXA.
RESULTS
Age was negatively, and body weight and c-calcium positively associated with spine and femur neck and total hip BMD. Hemoglobin was positively correlated with femur neck and total hip BMD. Total dose of EPO, iPTH, and alkaline phosphatase had no significant association with BMD. However, according to tertile of serum PTH concentration, BMD were worst in third tertile group. In multivariate linear regression analysis, age, weight, and serum PTH affect BMD.
CONCLUSIONS
BMD was independently related with age and weight. Hemoglobin correlated positively with femur neck and total hip BMD. However, treatment with EPO had no association with BMD. Increased PTH was related with reduced BMD.

Keyword

Bone mineral density; End-stage kidney disease; Erythropoietin; Hemoglobins

MeSH Terms

Alkaline Phosphatase
Anoxia
Body Weight
Bone Density
Bone Marrow
Calcium
Cross-Sectional Studies
Dialysis
Erythropoiesis
Erythropoietin
Femur Neck
Ferritins
Hemoglobins
Hip
Humans
Iron
Kidney Failure, Chronic
Linear Models
Male
Mesenchymal Stromal Cells
Parathyroid Hormone
Phosphorus
Spine
Alkaline Phosphatase
Calcium
Erythropoietin
Ferritins
Hemoglobins
Iron
Parathyroid Hormone
Phosphorus