Korean J Nephrol.  2000 May;19(3):437-443.

A Clinical Study of IgA Nephropathy with Serum Hepatitis B Surface Antigen

• Han GG
• Pack JH
• Bae SJ
• Ji SR
• Lim JH
• Jang GY
• Kim SE
• Kim KH

Abstract

There are some clinical evidences that hepatitis B virus(HBV) infection may cause IgA nephropathy. To evaluate clinical significances and pathogenetic roles of HBV infection in patients with IgA nephropathy, we studied that varius clinical and lab- oratory findings in 172 patients with IgA nephrop-athy as serum hepatitis B surface antigen (HBsAg) positive (19 cases) and negative group (153 cases). The result was as following: 1) The incidence of positive serum HRsAg was 11.0%(19/172 cases) in patients with IgA nephropathy and it was higher than that of the randomized age-sex matched general population(4.1%) but has no significance statistically. 2) There was no significant differences in incidence of hypertension, serum levels of IgA, C3, SGOT, SGFf between HBsAg postive and negative group. 3) The cases of nephrotic range proteinuria (3.5g/ day) was more prevalent in HBsAg positive group (31.6%) than that in negative group(7.2%). significantly (p<0.05). 4) The cases of impaired renal function (serum creatinine more than 1.4mg/dL) were more frequent in HBsAg positive group (42.19%) than that in neg-ative group (13.1%) significantly(p<0.05).

Keyword

IgA nephropathy; HBsAg; Pathoge-nesis; Prognosis

MeSH Terms

Aspartate Aminotransferases
Creatinine
Glomerulonephritis, IGA*
Hepatitis B Surface Antigens*
Hepatitis B*
Hepatitis*
Humans
Hypertension
Immunoglobulin A*
Incidence
Prognosis
Proteinuria
Aspartate Aminotransferases
Creatinine
Hepatitis B Surface Antigens
Immunoglobulin A