Korean J Nephrol.
1997 Jun;16(2):403-406.
A Case of Calciphylaxis in a Patient with Diabetic End Stage Renal Disease
- Affiliations
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- 1Department Interanl Medicine, Hallym University Medical College, Chuncheon, Korea.
- 2Department Pathology, Hallym University Medical College, Chuncheon, Korea.
Abstract
- Calciphylaxis is a rare but life-threatening complication in patients with end stage renal disease (ESRD). Clinical presentation consists of violaceous skin lesions that progress to nonhealing ulcers and gangrene. Secondary infection of skin lesions is common, often leading to sepsis and death. We report a case presenting in 15months after maintenance hemodialysis for diabetic ESRD with painful violaceous skin discoloration on distal fingers of both hands and toes of left foot. X-ray of both hands and left foot showed vascular calcification along the course of the arteries. Despite symptomatic treatement, skin lesions progressed to nonhealing ulcers and became necrotic, and amputation of the second and fifth fingers of right hand was required. The surgical biopsy specimen revealed circumferential calcium deposition in the intima and media of the arteries by von Kossa stain. Two months after the operation, the patient died of cachexia.
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