Korean J Nephrol.  2000 Sep;19(5):959-964.

A Case of Focal Segmental Glomerulosclerosis in Takayasu's Arteritis

• Kang SM
• Song YS
• Kim JS
• Yoon SY
• Lee RT
• Choi GH
• Cho SY
• Lee HY
• Han DS
• Jeong HJ

Abstract

Takayasu's arteritis(TA) is a chronic inflammatory and obliterative disease of medium- and large-sized arteries characterized by a strong predilection for the aortic arch and its branches. Renal involvement is usually manifested by renovascular hypertension. Glomerular involvement is rare and largely exists as a mild mesangial proliferative glomerulonephritis, commonly manifesting microscopic hematuria and proteinuria. The association of glomerular disease with TA is of interest since common immunologic mechanisms are proposed for the pathogenesis of both entities. We report a case of TA associated with focal segmental glomerulosclerosis. The patient presented with hypertension(Upper limb; Rt. 200/80mmHg, Lt. 95/60mmHg, Lower limb; Rt. 140/90mmHg, Lt. 110/70mmHg) and nephrotic syndrome(Serum albumin : 2.3g/dL, cholesterol : 454mg/dL, BUN : 18.0mg/dL, creatinine 1.3mg/dL, 24-hour urine protein : 5.17g). Digital substraction angiography showed multiple narrowing and occlusive changes of aortic arch and its branches. Renal biopsy was interpreted as focal segmental glomerulosclerosis. Therapy was instituted with prednisolone.

Keyword

Takayasu's arteritis; Focal segmental glomerulosclerosis

MeSH Terms

Angiography
Aorta, Thoracic
Arteries
Biopsy
Cholesterol
Creatinine
Extremities
Glomerulonephritis
Glomerulosclerosis, Focal Segmental*
Hematuria
Humans
Hypertension, Renovascular
Lower Extremity
Prednisolone
Proteinuria
Takayasu Arteritis*
Cholesterol
Creatinine
Prednisolone