Korean J Nephrol.  2002 Jul;21(4):691-696.

A Case of Rapidly Progressive Glomerulonephitis Associated with Anti-Glomerular Basement Membrane Antibody and p-Antineutrophilic Cytoplasmic Antibody

• Ryu JI
• Cho KH
• Heo SW
• Kwon HH
• Cho CH
• Ahn KS
• Lee IH

Abstract

Rapidly progressive glomerulonephritis(RPGN) is clinical syndrome characterized by rapid loss of renal function within several weeks to months, with histologic finding of extensive crescent formation. We report a case of RPGN associated with anti-glomerular basement membrane antibody(anti-GBM Ab) and perinuclear-antineutrophilic cytoplasmic antibody(p- ANCA), which rapidly progressed to chronic renal failure. A 44-year-old male was referred to our hospital for evaluation of pitting edema and proteinuria. Both anti-GBM Ab and p-ANCA were detected in serum. Percutaneous renal biopsy showed many crescents with some fibrinoid materials and heavy deposits of IgG. He was treated with pulse methylprednisolone, followed by oral corticosteroid and cyclophosphamide. In spite of immunosuppressive therapy, his renal function deteriorated rapidly and uremic symptoms including pulmonary edema were aggravated. He was started on hemodialysis and he has received regular hemodialysis without recovery of renal function. Further studies will be needed to determine the clinical significance of combined anti- GBM Ab and ANCA.

Keyword

Rapidly progressive glomerulonephritis; Chronic renal failure; Anti- glomerular basement membrane antibody; Antineutrophilic cytoplasmic antibody

MeSH Terms

Adult
Antibodies, Antineutrophil Cytoplasmic
Basement Membrane*
Biopsy
Cyclophosphamide
Cytoplasm*
Edema
Humans
Immunoglobulin G
Kidney Failure, Chronic
Male
Methylprednisolone
Proteinuria
Pulmonary Edema
Renal Dialysis
Antibodies, Antineutrophil Cytoplasmic
Cyclophosphamide
Immunoglobulin G
Methylprednisolone