Korean J Nephrol.
2011 Sep;30(5):506-515.
The Usefulness of Urinary Angiotensinogen as a Biomarker of Renal Progression in Autosomal Dominant Polycystic Kidney Disease
- Affiliations
-
- 1Department of Internal Medicine, Seoul National University College of Medicine, Korea.
- 2Department of Internal Medicine, Eulji General Hospital, Korea. ondahl@eulji.ac.kr
- 3Transplant Research Institute, Seoul National University Hospital, Korea.
- 4Department of Internal Medicine, Hallym University College of Medicine, Korea.
- 5Department of Internal Medicine, Sungkyunkwan University College of Medicine, Korea.
- 6Department of Internal Medicine, Gachon University of Medicine and Science, Korea.
- 7Department of Internal Medicine, The Catholic University of Korea College of Medicine, Korea.
Abstract
- PURPOSE
The renin-angiotensin-aldosterone system activation has been suggested as a potential risk factor for renal progression in autosomal dominant polycystic kidney disease (ADPKD). This study was performed to evaluate urinary angiotensinogen as a biomarker of renal progression in ADPKD.
METHODS
Patients with estimated glomerular filtration rate (eGFR) > or =30 mL/min/1.73m2 were enrolled in the study. Specimens (blood and urine) and computed tomography (CT) were taken from each subject. The eGFR was calculated by 4-variable MDRD equation and total kidney volume (TKV) was measured from CT images by modified ellipsoid method. Urinary angiotensinogen (AGT) and neutrophil gelatinaseassociated lipocalin (NGAL) were measured by ELISA. The concentration of AGT was adjusted with random urine creatinine (Cr). The association between urinary biomarkers, TKV and eGFR were evaluated.
RESULTS
A total of 59 (M:F=31:28) subjects were enrolled in the study and their mean age was 46 years. The eGFR and TKV at the enrollment were 77.3+/-15.6 mL/min/1.73m2 and 1389.8+/-925.1 mL, respectively. Log AGT/Cr was associated with TKV (r2=0.117, p=0.01) in the earlier stage of disease (TKV<3,000 mL). However, it did not show significant correlation with eGFR. Log NGAL was not associated with either TKV or eGFR. Urinary AGT/Cr was closely related to the number of anti-hypertensive medication, TKV, and the presence of albuminuria, although there was no correlation with plasma renin activity or aldosterone level.
CONCLUSION
Urinary angiotensinogen may be a useful biomarker of disease progression in ADPKD patients.
MeSH Terms
-
Albuminuria
Aldosterone
Angiotensinogen
Biomarkers
Creatinine
Disease Progression
Enzyme-Linked Immunosorbent Assay
Glomerular Filtration Rate
Humans
Kidney
Lipocalins
Neutrophils
Organ Size
Plasma
Polycystic Kidney Diseases
Polycystic Kidney, Autosomal Dominant
Renin
Renin-Angiotensin System
Aldosterone
Angiotensinogen
Creatinine
Lipocalins
Renin
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