Korean J Med.
2006 Mar;70(3):261-267.
The cystic neoplasms of the pancreas in Korea
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea. yyb10604@plaza.snu.ac.kr
- 2Center for Liver Cancer, National Cancer Center, Goyang, Korea.
- 3Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 4Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
- 5Department of Internal Medicine, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
- 6Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
- 7Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, Korea.
- 8Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.
- 9Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 10Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea.
- 11Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
- 12Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
- 13Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
- 14Department of Internal Medicine, Soonchunhyang University Medical College, Seoul, Korea.
- 15Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Abstract
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BACKGROUND: Cystic neoplasms of the pancreas are being recognized with increased frequency. In 1993, a report on 123 cases of cystic neoplasms of the pancreas diagnosed over a period of 32 years was published in Korea. Many changes on the concept of cystic neoplasms of the pancreas have been made, including classification and diagnostic criteria. The present study was conducted wherein a new survey on cystic neoplasms of the pancreas in Korea.
METHODS
Cystic neoplasms of the pancreas diagnosed over a period of 12 years, from 1993 to 2004 in 25 university hospitals throughout Korea were collected. They were classified according to the World Health Organization classification of cystic neoplasms of the pancreas.
RESULTS
A total of 1264 cases of cystic neoplasms of the pancreas were diagnosed. The diagnoses and frequencies are as follows: intraductal papillary mucinous neoplasm, 499 (39.5%); mucinous cystic neoplasm, 318 (25.2%); serous cystic neoplasm, 232 (18.4%); solid pseudopapillary neoplasm, 192 (15.2%); cystic endocrine neoplasm, 11 (0.8%); lymphoepithelial cyst, 8 (0.6%); acinar cell neoplasm, 3 (0.2%); mature teratoma, 1 (0.1%). Increase in the annual number of diagnoses was evident. In intraductal papillary mucinous neoplasm and mucinous cystic neoplasm, a significant increase in mean age was seen in patients with malignant neoplasms.
CONCLUSIONS
Cystic neoplasms of the pancreas are diagnosed with increasing frequency in Korea, the most common being intraductal papillary mucinous neoplasm of the pancreas. In intraductal papillary mucinous neoplasm and mucinous cystic neoplasm, the grade of dysplasia increased with mean age, suggesting an adenoma-carcinoma sequence.
