Korean J Hematol.  2012 Mar;47(1):74-76. 10.5045/kjh.2012.47.1.74.

Asymptomatic pneumatosis intestinalis following chemotherapy for B lymphoblastic leukemia with recurrent genetic abnormalities in an adolescent patient

  • 1Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
  • 2Division of Hemato-Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea. sychong@cha.ac.kr


Pneumatosis intestinalis (PI) is a rare condition characterized by multiple pneumocysts in the submucosa or subserosa of the bowel. Here, we report a rare case of asymptomatic PI after chemotherapy induction in an 18-yr-old man with B lymphoblastic leukemia with recurrent genetic abnormalities. The patient was treated conservatively and recovered without complications. The possibility of PI should be considered as a complication during or after chemotherapy for hematologic malignancies. Conservative treatment should be considered unless there are complications, including peritonitis, bowel perforation, and severe sepsis.


Pneumatosis intestinalis; B lymphoblastic leukemia with recurrent genetic abnormalities; Chemotherapy

MeSH Terms

Hematologic Neoplasms
Precursor Cell Lymphoblastic Leukemia-Lymphoma


  • Fig. 1 Chest X-ray demonstrating perigastric and pericolic gas accumulation.

  • Fig. 2 Abdominal X-ray demonstrating a hyperlucent shadow along the entire colon.

  • Fig. 3 (A) Abdominal computed tomography (CT) image revealed pneumoperitoneum and pneumoretroperitoneum. (B) Abdominal CT image showed intramural and extramural gas of the ascending and transverse colon. It is seen more easily using a lung window setting.


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