Korean J Med.  1997 Jan;52(1):126-130.

A Case of Immunoglobulin Deficiency with increased IgM

• Lim JS
• Ryu SH
• Yu DS
• Ryu IY
• Yun SJ
• Lee JH
• Sin WH
• Hwang SC

Abstract

Immunoglobulin deficiency with increased IgM, as defined by World Health Organization classification of primary immunodeficiency, is characterized by normal or increased concentrations of serum IgM and, in some cases, IgD, but decreased or absent IgG, IgA, and IgE. Patients with these disorders have a high incidence of recurrent pyogenic infections, including otitis media, pneumonia, and septisemia. We recently experienced a case of immunoglobulin deficiency with increased IgM in a 25-year old man. He had been suffered from recurrent pyogenic infections-pneumonia, otitis media-since about 6 months of his age. He was admitted due to pneumonia, and Haemophilus influenza was isolated from the sputum culture. Also chest X-ray showed bronchiectasis. His serum immunoglobulin levels revealed increased concentration of IgM and decreased IgG and IgA. He was successfully treated with antibiotics, and now he is being followed-up. So we present this case with the review of literature.

Keyword

Immunoglobulin deficiency with increased IgM; recurrent pyogenic infections

MeSH Terms

Adult
Anti-Bacterial Agents
Bronchiectasis
Classification
Haemophilus
Humans
Immunoglobulin A
Immunoglobulin D
Immunoglobulin E
Immunoglobulin G
Immunoglobulin M*
Immunoglobulins*
Incidence
Influenza, Human
Otitis
Otitis Media
Pneumonia
Sputum
Thorax
World Health Organization
Anti-Bacterial Agents
Immunoglobulin A
Immunoglobulin D
Immunoglobulin E
Immunoglobulin G
Immunoglobulin M
Immunoglobulins