Korean J Med.  1998 Sep;55(3):427-431.

A Case of Behcet's Disease Associated with Protein S Deficiency

• Song JS
• Park W

Abstract

Protein S is a natural anticoagulant present in the plasma that serves as a cofactor for activated protein C. The protein S level is decreased in congenital deficiency, inflammatory syndrome, DIC, hepatic disorders, malignancy, and oral anticoagulant (warfarin) therapy. Protein S deficiency provokes recurrent thromboembolism, superficial and/or deep vein thrombosis. Behcet's disease is a multisystemic disorder presenting with recurrent oral and genital ulcerations as well as ocular involvement. The mechanism of vascular involvement of Behcet's disease is not fully understood. This is a case report of Behcet's disease associated with protein S deficiency in a 44 year old male patient with deep vein thrombosis. We report the case with relevant literature review.

Keyword

Behcet's disease; Protein S deficiency

MeSH Terms

Adult
Dacarbazine
Humans
Male
Plasma
Protein C
Protein S Deficiency*
Protein S*
Thromboembolism
Ulcer
Venous Thrombosis
Dacarbazine
Protein C
Protein S