Korean J Dermatol.  2011 Jul;49(7):601-605.

Cutaneous Granulomas Associated with Common Variable Immunodeficiency

Affiliations
  • 1Department of Dermatology, Inha University School of Medicine, Incheon, Korea. jshin@inha.ac.kr

Abstract

Common variable immunodeficiency (CVID) is one of the primary immunodeficiency disorders, which is characterized by hypogammaglobulinemia, defect in antibody synthesis and recurrent sinorespiratory bacterial infections. Granuloma is an uncommon skin manifestation in primary immunodeficiency disorders. Here we present a 5-year-old girl who had asymptomatic erythematous plaques on the face and legs. She had a past medical history of recurrent sinorespiratory and gastrointestical bacterial infections since 2 years old. The histopathologic findings of the skin lesions showed sarcoid-like granulomas with focal necrobiosis. No specific organism was found with evaluation. Cells forming granulomas were strongly positive for CD3 or CD68. CD4/CD8 ratio was estimated less than 1. Laboratory examination showed low hemoglobin, low B cell and normal T cell number, low IgA and IgG levels.

Keyword

Cutaneous granuloma; Immunodeficiency; Sarcoid

MeSH Terms

Agammaglobulinemia
Bacterial Infections
Cell Count
Common Variable Immunodeficiency
Granuloma
Hemoglobins
Immunoglobulin A
Immunoglobulin G
Leg
Necrobiotic Disorders
Preschool Child
Skin
Skin Manifestations
Hemoglobins
Immunoglobulin A
Immunoglobulin G
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