J Gynecol Oncol.  2009 Jun;20(2):122-125. 10.3802/jgo.2009.20.2.122.

A case of multiple metastatic low-grade endometrial stromal sarcoma arising from an ovarian endometriotic lesion

Affiliations
  • 1Department of Obstetrics and Gynecology, School of Medicine, Catholic University of Daegu, Daegu, Korea. sbko@cu.ac.kr
  • 2Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu, Korea.

Abstract

The development of endometrial stromal sarcomas (ESSs) in foci of endometriosis is extremely rare, and few cases have been reported in the literature to date, particularly with regard to multiple extrauterine ESS. Here we report a case of endometrial stromal sarcoma with multiple metastasis that arose from an ovarian endometriotic lesion. The literature is also briefly reviewed.

Keyword

Endometrial stromal sarcomas; Endometriosis; Ovary

MeSH Terms

Endometriosis
Female
Neoplasm Metastasis
Ovary
Sarcoma, Endometrial Stromal

Figure

  • Fig. 1 Computed tomography showing a necrotic solid mass measuring 7 cm in diameter on the left adnexa (B), a huge para-aortic solid mass lesion, and left renal vein and inferior vena cava thrombosis, which is suggestive of nodal metastasis (A, C). (A, B) axial image, (C) coronal image.

  • Fig. 2 Gross findings of the left ovary. The cut surface shows a diffuse dark reddish hemorrhagic lesion containing a solid focal yellowish lesion.

  • Fig. 3 Microscopic findings of the left ovary. The sections of the left ovary exhibit perivascular whorling proliferation of plump and spindle cells with a scanty cytoplasm and indistinct cell borders (A, hematoxylin-eosin, ×200; B, hematoxylin-eosin, ×400). Immunohistochemical staining analyses revealed that the neoplastic cells were immunoreactive to CD10 (C, ×400) and ER (D, ×400).


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