Clinical Analysis of Multiple Primary Carcinoma Associated with Gynecologic Malignancies

Noh, Heung Tae; Rhee, Yun Ee; Son, Sung Kyong

Abstract

OBJECTIVE
: The frequency of multiple primary carcinoma is increasing as a result of the lengthening average lifetime, progress in cancer screening technique, and improved cancer therapy. The purpose of this study was to investigate the clinicopathologic findings, treatment modalities and outcomes of patients with multiple primary carcinoma.
METHODS
: From Jan. 1991 to Dec. 2003, 27 patients with multiple primary carcinoma managed in the department of obstetrics and gynecology of Chungnam National University Hospital were evaluated for their clinical profiles and survival.
RESULTS
: The mean age of patients with multiple primary carcinoma was 48.6 years. The most common presenting symptom was abnormal uterine bleeding. In multiple primary carcinoma, 13 out of 27 cases showed synchronous type, 14 cases indicated metachronous type. 12 patients showed multiple primary carcinoma including ovarian carcinoma which is the most prevalent case. 12 out of 27 cases demonstrated identical pathology, while 15 cases indicated different pathology. Surgery, adjuvant radiotherapy and chemotherapy were used as the treatment methods. During follow up period, 20 of 27 cases were survived, 8 cases have been followed up without any prove of recurrence and metastasis and 7 out of them died.
CONCLUSION
: Since the number of the patients with multiple primary carcinoma tend to increase, when the patients with malignant tumor are founded, the diagnosis process to find out another tumor and close management for the patients are necessary.