J Genet Med.  2009 Jun;6(1):62-66.

A Cytogenetic Analysis of Abortus with Spontaneous Abortion

• Hwang SM
• Kwon KH
• Yoon KA
• Oh SK

Abstract

PURPOSE
Chromosomal abnormalities of abortuses have been used to investigate common etiologies of spontaneous abortion, but the frequencies and types of spontaneous abortions have demonstrated considerable variation among different countries and races.
MATERIALS AND METHODS
A cytogenetic analysis of 75 abortuses was performed at GenDix, Inc. from January 2006 to December 2007.
RESULTS
The frequency of chromosome abnormalities in abortuses was 32.0% (24/75 cases). Among the chromosomal abnormalities, trisomy was present in 62.5% (15/24 cases) of cases and the most frequent trisomy was trisomy 21 with an occurrence rate of 26.6% (4/15 cases). The following was trisomy 22 (3/15 cases) and trisomy 20 (2/15 cases). The average maternal age for abnormal karyotypes was 34.3+/-3.3.
CONCLUSION
Cytogenetic analysis of abortus is important for diagnosis and genetic counseling of patients with spontaneous abortion.

Keyword

Chromosome; Abortus; Karyotype

MeSH Terms

Abnormal Karyotype
Abortion, Spontaneous
Chromosome Aberrations
Chromosomes, Human, Pair 20
Chromosomes, Human, Pair 22
Cytogenetic Analysis
Cytogenetics
Down Syndrome
Female
Genetic Counseling
Humans
Karyotype
Maternal Age
Mosaicism
Pregnancy
Trisomy
Chromosomes, Human, Pair 20
Chromosomes, Human, Pair 22
Mosaicism
Trisomy