Korean J Gynecol Oncol.
2007 Dec;18(4):299-307.
Rb pathway alteration and E2F-1 expression in epithelial ovarian cancer
- Affiliations
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- 1Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Busan, Korea. msyoon@pusan.ac.kr
- 2Department of Pathology, College of Medicine, Pusan National University, Busan, Korea.
Abstract
OBJECTIVE
To evaluate the clinicopathological implications of Rb pathway alteration and E2F-1 expression in Epithelial ovarian cancer using immunohistochemical staining.
METHODS
Tissue samples (n=72) were collected after staging operation between 1998 and 2004.
RESULTS
In 72 cases, the overall expression of pRb, and E2F-1 were 59.7% (43/72), and 58.3% (42/72), respectively. pRb expression was inversely correlated with stage, histologic grade and mitotic index. E2F-1 expression was correlated with advanced stages, high grade, mitotic index, Ki-67 labeling index (LI).
CONCLUSION
We suggest that Rb pathway alteration and E2F-1 expression could play roles as a new prognostic factors in Epithelial ovarian cancer.
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