Korean J Gastrointest Endosc.  1987 Nov;7(1):39-41.

Russell Body - Containing Plasma Cell Aggregations Mimiccking Signet Ring Cell Carcinoma of the Stomach

• Yu ES
• Kim YI
• Kim CW
• Kim WH

Abstract

This report presents a case with gastric ulcer whose gastric mucosal biopsy revealed heavy aggregations of Russell body containing plasma cells in the lamina propria and in peptic detritus. A sixty four year old female received an endoscopic examination for currently aggravated peptic ulcer symytoms, It revealed a small round ulcer with nodular margin along the greater curvature of high body, suggesting of early gastric carcinoma. Endoscopic biopsies (two times) confirmed heavy collections of Russell body-containing plasma cells which were once misinterpreted as signet ring cell carcinoma. Immonohistochemically they were strongly positive to both kappa and lambda light chains by pgtroxidase-antiperoxidase method. Each infiltrated cell contained one or more refractile intracytoplasmic eosinophilic globules, bcing associated with extracellular ones and heavy matare lympho-plasma cell infiltration. Differential diagnosis from neoplastic signet ring cells in endoscopic biopsy was diseussed.

MeSH Terms

Biopsy
Carcinoma, Signet Ring Cell*
Diagnosis, Differential
Eosinophils
Female
Humans
Mucous Membrane
Peptic Ulcer
Plasma Cells*
Plasma*
Stomach Ulcer
Stomach*
Ulcer