Korean J Anesthesiol.  1999 Sep;37(3):447-452. 10.4097/kjae.1999.37.3.447.

Preemptive Analgesic Effect of Magnesium Sulfate on Postoperative Pain after Hysterectomy

• Oh KJ
• Heo MS
• Ko SH
• Han YJ
• Choe H

• KMID: 2240047
• DOI: http://doi.org/10.4097/kjae.1999.37.3.447

Abstract

BACKGROUND: Recent studies suggest that preoperative block of the N-Methyl-D-Aspartate (NMDA) receptor with NMDA antagonists may reduce postoperative pain. We infused magnesium sulfate, anatural NMDA receptor antagonist, preoperatively to evaluate the preemptive analgesic effect of magnesium.
METHODS
Sixty healthy patients who underwent total abdominal hysterectomy under general sthesia were randomly divided into three groups. Group 1 was the control group, while Groups 2 and 3 received intravenous magnesium (Group 2 : 0.1 mg/kg bolus, 0.015 mg/kg/hr for 6hr, Group 3 : 0.2 mg/kg bolus, 0.03 mg/kg/hr for 6hr). Postoperative pain scorers (Visual Analog Scale: VAS and Prince Henry Score: PHS) and the amount of analgesic consumption were evaluated at 6, 24, 48 and 72 hours by a double blind manner.
RESULTS
The patients in Group 3 had lower pain scores at 6 and 24 hours compared to those in Group 1, but there were no significant differences in PHS and cumulative amounts of analgesic consumption among the three groups.
CONCLUSIONS
The preoperative administration of intravenous magnesium reduced postoperative pain scores. However, further study is needed before its clinical use for postoperative analgesic purposes.

Keyword

Analgesia, preemptive; Ions, magnesium; Pain, postoperative

MeSH Terms

Humans
Hydrogen-Ion Concentration
Hysterectomy*
Magnesium Sulfate*
Magnesium*
N-Methylaspartate
Pain, Postoperative*
Magnesium
Magnesium Sulfate
N-Methylaspartate