Korean J Anesthesiol.  2007 May;52(5):516-520. 10.4097/kjae.2007.52.5.516.

Desflurane-induced Hemodynamic Changes in Patients with Hypertension

• Kim EA
• Lee JW
• Lim HS
• Son JS
• Ko SH

• KMID: 2239867
• DOI: http://doi.org/10.4097/kjae.2007.52.5.516

Abstract

BACKGROUND: A rapid increase in the desflurane concentration induces tachycardia and hypertension and increases the plasma catecholamine concentration. This study compared the desflurane-induced hemodynamic responses in hypertensive patients with those of normotensive patients.
METHODS
Sixty patients, 30 normotensive patient (group 1) and 30 hypertensive patients (group 2), were scheduled to undergo elective surgery under general anesthesia. The hypertensive patients have been taking regular antihypertensive drugs and their blood pressure and heart rate was well controlled. Thirty normotensive patients were not premedicated. The inspired concentration of desflurane through the mask was increased abruptly to 12.0 vol%. The target was to produce an end-tidal concentration of desflurane (ETdesf) of 10.0 vol% which was maintained until the end of the study by adjusting the vaporizer dial setting. The heart rate (HR), blood pressure (BP), cardiac index (CI), systemic vascular resistance (SVR), ETdesf, end-tidal concentration of carbon dioxide, and peripheral oxygen saturation were measured at the baseline and every 30 seconds for 5 minutes after inhaling of desflurane and for 2 minutes after intubation.
RESULTS
The HR, BP, and CI increased significantly in the two groups compared with the baseline. However, the HR, blood pressure, CI, SVR, and ETdesf were similar in both groups. In addition, there were no significant differences of hemodynamic changes between the beta-blocker and the calcium channel blocker in the hypertensive patients.
CONCLUSIONS
In patients with well-controlled hypertension, the hemodynamic responses to desflurane are similar to those in normotensive patients.

Keyword

desflurane; hemodynamic response; hypertension

MeSH Terms

Anesthesia, General
Antihypertensive Agents
Blood Pressure
Calcium Channels
Carbon Dioxide
Heart Rate
Hemodynamics*
Humans
Hypertension*
Inhalation
Intubation
Masks
Nebulizers and Vaporizers
Oxygen
Plasma
Tachycardia
Vascular Resistance
Antihypertensive Agents
Calcium Channels
Carbon Dioxide
Oxygen