Korean J Anesthesiol.  1991 Feb;24(1):134-138. 10.4097/kjae.1991.24.1.134.

Comparison between the continuous Infusion and the Intermittent Administration of Vecuronium

• Lee CE
• Ahn CK
• Kim HK

• KMID: 2239381
• DOI: http://doi.org/10.4097/kjae.1991.24.1.134

Abstract

The neuromuacular blocking effects of the repeated bolus injection and continuous injection of vecuronium have been compared in 20 patients by means of evoked twitch tension. Group I received a loading dose (0.08 mg/kg) of vecuronium and followed by maintenance doae (0.02 mg/kg) when twitch tension had recovered to 25% of control. Group II received a loading doses (0. 08mg/kg) of vecuronium plus a continuous infusion delivering 0.06 mg/kg/hr. Anesthesia was maintained with nitrous oxide, oxygen and 1.5% enflurane. The neuromuscular blocking effect were reversed by the neostigmine 1.0 mg and robinul 0.2 mg when twitch tension had recovered 25% control in both groups near the end of operation. With repeated injection of vecuronium (group I), the duration of blockade of 25% recovery was 21.6+/-4.2 minutes and the recovery times from 25% to 75% was 6.8+/-1.9 minutes The continuous infusion of vecuronium (group II) produced consistent neuromuscular blockade at the average level of 90% twitch depression. The times from the end of infusion to 25% and fr,om 25% to 75% are averaged 16.0+/-2.5 and 4.2+/-0.7 minutes respectively. The reeovery index was more rapid in infusion group than maintenance group (P<0.05).

Keyword

Vecuronium; Infusion

MeSH Terms

Anesthesia
Depression
Enflurane
Humans
Neostigmine
Neuromuscular Blockade
Nitrous Oxide
Oxygen
Vecuronium Bromide*
Enflurane
Neostigmine
Nitrous Oxide
Oxygen
Vecuronium Bromide