Korean J Anesthesiol.  1994 Feb;27(2):136-142. 10.4097/kjae.1994.27.2.136.

The Effect of Continuous Intravenous Infusion of Esmolol on the Hemodynamic Changes Following Endotracheal Intubation

• Kong MH
• Lim HJ
• Chae BK
• Chang SH

• KMID: 2239203
• DOI: http://doi.org/10.4097/kjae.1994.27.2.136

Abstract

The changes in heart rate, systolic, mean and diastolic arterial blood pressure, and the plasma concentration of epinephrine and norepinephrine were measured before and thmughout the induction periods of anesthesia in 60 elective surgical patients in a randomized, double-blind manner to evaluate the effects of continuous intravenous infusion of esmolol for 1 minute at 500 ug/kg/min as a loading dose and for 4 minutes at 100 ug/kg/min as a maintenance dose. The control group (n=30) was given the continuous infusion of normal saline at the same volume-rate. During the study, anesthesia was maintained with N2O-O2-enflurane-vecuronium and controlled ventilation. In the esmolol group, statisticaUy, the heart rate at 1 minute after the intubation was less increased and systolic and diastolic pressure after 11 minutes were more decreased than the control group. And plasma norepinephrine concentration was elevated more than the control group at 3 minutes after the intubation. We concluded that the used infusion rate of esmolol blunted the hemodynamic changes following the laryngoscopy and endotracheal intubation but it is still needed to find the dosage for complete blocking the adrenergic response.

Keyword

Endotracheal intubation; Hemodynamics; Esmolol; Continuous infusion

MeSH Terms

Anesthesia
Arterial Pressure
Blood Pressure
Epinephrine
Heart Rate
Hemodynamics*
Humans
Infusions, Intravenous*
Intubation
Intubation, Intratracheal*
Laryngoscopy
Norepinephrine
Plasma
Ventilation
Epinephrine
Norepinephrine