Korean J Anesthesiol.  2002 Sep;43(3):345-347. 10.4097/kjae.2002.43.3.345.

The Relationship of the Estimates of Effective Concentration Calculated by Logit, Probit, and Sigmoid Emax

• Lee SI
• Hwang GB
• Baik CY

• KMID: 2238979
• DOI: http://doi.org/10.4097/kjae.2002.43.3.345

Abstract

BACKGROUND: This study is to demonstrate that the estimates of effective concentration (EC) inferred by logit, probit, and sigmoid Emax can be declared to be similar.
METHODS
The estimates of EC (5, 25, 50, 75, 95 [%]) of 24 vecuronium concentration-single twitch response data were obtained with three pharmacodynamic methods. A paired t-test with Bonferroni's correction was used.
RESULTS
The distribution of estimates by probit were narrower than that of those by logit and sigmoid Emax. The estimates of logit and sigmoid Emax were closely similar.
CONCLUSIONS
It suggests that the EC estimates of other paper analysed by the different pharmacodynamic method could be lower or higher.

Keyword

Logit; pharmacodynamics; probit; sigmoid Emax

MeSH Terms

Colon, Sigmoid*
Vecuronium Bromide
Vecuronium Bromide