Korean J Anesthesiol.  2005 Feb;48(2):145-148. 10.4097/kjae.2005.48.2.145.

The Dose-Dependent Analgesic Effect of Ondansetron for Pain on Injection of Rocuronium in Adult

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, College of Medicine, Chosun University, Gwangju, Korea. kyso@mail.chosun.ac.kr

Abstract

BACKGROUND: Intravenous injection of rocuronium produces intense discomfort at the site of injection in conscious patient. The purpose of this study was 2 folds; First, to determine the incidence of pain associated IV injection of rocuronium in adult patients. Second, to determine whether pretreatment with IV ondansetron affects the incidence of pain associated with the injection of rocuronium.
METHODS
Eighty adult patients were randomly assigned to four groups. Before general anesthesia was induced with thiopental sodium (5 mg/ml), manual occlusion (70 mmHg) with tourniquet of venous inflow was performed. Randomly associated 20 patients received 4 ml of normal saline as a placebo control (Group 1). Other 60 patients allocated randomly to one of three groups: ondansetron 4 mg (Group 2), 6 mg (Group 3), 8 mg (Group 4) respectively. The patients' pain response to rocuronium injection was graded with using Memis' 4-point scale and withdrawal response was graded with using Kim's 4-point scale.
RESULTS
Nineteen patients (95%) in the group 1, 18 patients (90%) in the group 2, 19 patients (95%) in the group 3, and 14 patients (85%) in the group 4 reported pain. Moderate to sever pain was 17 patients (85%), in the group 1, 11 patients (55%) in the group 2, 9 patients (45%) in the group 3, and 1 patient (5%) in the group 4.
CONCLUSIONS
Ondansetron 4 mg, 6 mg, and 8 mg IV given before administration of rocuronium did not reduce incidence of pain on injection of rocuronium but significantly reduced severity of pain on injection of rocuronium and the 8 mg was more effective.

Keyword

ondansetron; pain; rocuronium

MeSH Terms

Adult*
Anesthesia, General
Humans
Incidence
Injections, Intravenous
Ondansetron*
Thiopental
Tourniquets
Ondansetron
Thiopental
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