Korean J Anesthesiol.  1989 Feb;22(1):53-59. 10.4097/kjae.1989.22.1.53.

Effect of Dextran 40 on Platelet Function

• Lim HJ
• Park YC
• Shin JS

• KMID: 2237913
• DOI: http://doi.org/10.4097/kjae.1989.22.1.53

Abstract

Dextran is a macromolecular polymer of dextrose. Dextran is used as a plasma expander with reduction in blood viscosity and disruption of red cell aggregates. It also inhibits platelet aggregation and prothrombin activation. It has been reported that a hemostatic defect characterized by a prolonged bleeding time in subject receiving large amount of dextran. The present study was undertaken to observe the effect of dextran on bleeding time and platelet aggregation by increasing volume. In this study, bleeding time was checked and sampling was done at before infusion, after 5 ml/kg, 10 ml/kg and 15 ml/kg infusion of dextran in 15 patients with spinal or regional anesthesia. The results were as follows: 1) There was prolonged bleeding time by increasing volume of dextran 40, but within nonnal limit. 2) There was no platelet aggregation with 15ml/kg of dextran.

MeSH Terms

Anesthesia, Conduction
Bleeding Time
Blood Platelets*
Blood Viscosity
Dextrans*
Glucose
Humans
Plasma
Platelet Aggregation
Polymers
Prothrombin
Dextrans
Glucose
Polymers
Prothrombin