Korean J Anesthesiol.  2004 Jul;47(1):12-16. 10.4097/kjae.2004.47.1.12.

Effects of Intravenous Induction Drugs on Intubation Conditions Using Rocuronium for Rapid Sequence Induction

• Kim HJ
• Shin YS

• KMID: 2237549
• DOI: http://doi.org/10.4097/kjae.2004.47.1.12

Abstract

BACKGROUND: We assessed the effect of intravenous induction agents on intubation conditions and hemodynamic changes when using rocuronium 0.7 mg/kg for rapid sequence induction.
METHODS
Sixty ASA class I or II patients undergoing elective surgery were divided into a thiopental group (5 mg/kg, n = 20), a propofol group (2 mg/kg, n = 20) and an etomidate group (0.2 mg/kg, n = 20). Anesthesia was induced with intravenous induction agents. After loss of consciousness, rocuronium 0.7 mg/kg was injected. Intubation was attempted at 60 seconds after rocuronium administration. Arterial blood pressure and heart rate were measured before induction, immediately after intubation, and 1, 3, 5, and 10 minutes after intubation. Intubation conditions were assessed by jaw relaxation, vocal cord movement, response to tracheal intubation, and were evaluated as excellent, good, fair, and poor.
RESULTS
Excellent intubation conditions were obtained 55% (n = 11) in the thiopental group, 60% (n = 12) in the propofol group, and 45% (n = 9) in the etomidate group. Systolic and diastolic arterial blood pressures were elevated after intubation in all three groups. But these changes were minimal in the propofol group.
CONCLUSIONS
Intubation conditions were not significantly different after the intravenous injection of thiopental 5 mg/kg, propofol 2mg/kg, or etomidate 0.2 mg/kg when using rocuronium 0.7 mg/kg for rapid sequence induction.

Keyword

etomidate; intubation condition; propofol; rocuronium; thiopental sodium

MeSH Terms

Anesthesia
Arterial Pressure
Etomidate
Heart Rate
Hemodynamics
Humans
Injections, Intravenous
Intubation*
Jaw
Propofol
Relaxation
Thiopental
Unconsciousness
Vocal Cords
Etomidate
Propofol
Thiopental