A Case of Squamous Cell Carcinoma Arising in Nevus Sebaceus

Kang, Jin Moon; Kim, Hong Sik; Chung, Seum; Lee, Min Geol

Abstract

Various types of appendage tumors develop secondarily within lesions of nevus sebaceus. A syringocystadenoma papilliferum is the most common benign tumor while basal cell carcinoma is the most common malignant tumor developed within a nevus sebaceus. However, a squamous cell carcinoma rarely develops within a nevus sebaceus, although it may be aggressive. We report a case of a 44 year-old man who had a fingertip-sized hemorrhagic crusted mass in a 3x4cm sized nevus sebaceus which had developed since birth on the right occipital scalp. This mass has rapidly enlarged into 1x2cm sized growth in the past 4 months. Histopathologic examination of the lesion showed that infiltrative squamous cell carcinoma with good or moderate differentiation indicatied the lesion of nevus sebaceus. Wide excision of squamous cell carcinoma including the whole lesion of nevus sebaceus was performed. Three months later, squamous cell carcinoma recurred in the same part of the scalp. Another wide excision of the recurrence was performed, but recurred again in the same part with invasion into the muscle layer. The recurrence is currently being treated by radiotherapy.