Korean J Dermatol.  1978 Aug;16(4):311-317.

A Study on the Effectiveness of Clocortolone Pivalate (Purantix) Gream on Certain Common Skin Diseases

• Suk HS
• Kim YP

Abstract

In order to evaluate the effectiveness of clocortolone pivalate(Purantix) on corticosteroid responsive dermatoses, a symmetical paired. comparison technique was performed using 0. 1% clocortolone pivalate and 0. 025% triamcinolone acetonide creams. During the pericd of 7 months from September 1977 to March 1978, 37 patients with bilateral lesions of contact dermatitis, seborrheic dermatitis atopic dermatitis, lichen simplex chronicus and psoriasis were selected and treated with afore mentioned drugs, In the 15 psoriatic patients, clocrtolone pivalate was superior in 3, triamcinolone acetonide was superior in 2, 4oth drugs were equally effective in 10. In the evaluation of all 37 patients clocortolone pivalate was superior in 8, triamcinolone acetonide was sureior in 3, both drugs were equally effective in 26. The overall superiority of clocortolone pivalate to triamcinolone acetonide was non significant, There was no side effects with either drug. The simplicity of the vasoconstriction tcst has led to its general use in the study of the potency of new topical steroids. In the 6h occluded single-application vasocon-strictor test performed on 40 healthy students, there was no significant difference between clocortolone pivalate and triamcinolone acetonide, but they significantly d.ifferent from 1% hydrocortisone and the control; a simple ointment base(p<0.01).

MeSH Terms

Dermatitis, Atopic
Dermatitis, Contact
Dermatitis, Seborrheic
Humans
Hydrocortisone
Neurodermatitis
Psoriasis
Skin Diseases*
Skin*
Steroids
Triamcinolone Acetonide
Vasoconstriction
Hydrocortisone
Steroids
Triamcinolone Acetonide