A Study on Anlaysis of Patch Test Positive Reactivity according to the Reading Time

Kim, Jeong Aee

Abstract

Since the standard recommendation by the International Contact Dermatitis Research Group, day 2 and day 4 patch test readings have been performed by most dermatologists. However, nearly half of positive reactions can be observed only either on day 2 or on day 4 and the interpretation of these reactions is a problem. We compared the patch test reaction according to the reading time in 754 patients who had been performed patch test with standard battery and in 367 patients who had been performed patch test with various cosmetic allergens including cosmetics as is. The study result is summoized as follows : 1. Persistent reactions were observed in 59.8% patients tested with standard battery, however transient reactions were observed in 20.8% and delayed reaction in 19.4%. 2. Frequent allergens which showed transient reaction were carba mix, paraben mix, tego, imidazolidinyl urea, in order of frequency. Frequent allergens which showed late reactions were neomycin sulfate, quinidine mix, farmaldehyde, and imidazolidinyl urea. 3. Persistent reactions were observed in 47.1% patients. tested with cosmetics as is, however transient reactions were observed in 29.4% and delayed reactions in 23.5%, Facial skin care products showed the i,.st high positivity. 4. Persistent reactions were observed in 41.0% patients tested with cosmetics ingredients, however transient reactions were observed in 38.7% and delayed reactions in 23.0%. Frequent cosmetic allergens were cinnamic alcohol, cinnamic aldehyde, ylang ylang oil, sandawood oil, and benzyl salicylate. In conclusion, the reaction pattern in general was similar to the dats of others. However, the individual allergens showed transient reaction were somewhat different. Higher rate of transient reactions were observed in patch test positive reactions with cosmetic ingredients than standard battery and cosmetics as is.